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Lunesta, also known by its generic name eszopiclone, is a medication primarily used for the treatment of insomnia. In this 1000-word essay, I will provide an overview of Lunesta, including its uses, mechanism of action, dosage, side effects, and precautions. Insomnia is a common sleep disorder characterized by difficulty falling asleep, staying asleep, or experiencing non-restorative sleep. It can significantly impact a person’s quality of life, leading to daytime drowsiness, fatigue, mood disturbances, and impaired cognitive function. Lunesta is classified as a nonbenzodiazepine hypnotic medication and is commonly prescribed to help individuals with insomnia.

eszopiclone  works by enhancing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter in the brain that inhibits the transmission of signals. By increasing the effects of GABA, Lunesta helps to induce sleep and maintain a continuous sleep state throughout the night.

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Unlike benzodiazepines, eszopiclone has a shorter half-life, which means it is eliminated from the body more quickly, reducing the likelihood of residual sedation and next-day drowsiness. The recommended starting dosage of eszopiclone for adults is 1 mg, taken orally immediately before bedtime. However, in some cases, a higher dose of 2 mg may be prescribed if the lower dose is ineffective.

It is important to follow the prescribing physician’s instructions regarding dosage and duration of treatment. Elderly individuals and those with liver impairment may require a lower initial dose of 1 mg. eszopiclone should be taken on an empty stomach or at least 2 hours after a meal to ensure optimal absorption. Like any medication, eszopiclone has potential side effects. The most common side effects reported include headache, dry mouth, unpleasant taste, dizziness, and daytime drowsiness.

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These side effects are generally mild and transient. However, if they persist or worsen, it is important to consult a healthcare professional. Rare but more severe side effects may include allergic reactions, abnormal behavior, and memory loss. If any unusual or serious side effects occur, immediate medical attention should be sought.

eszopiclone should be used with caution in certain populations. It is not recommended for individuals with a history of drug or alcohol abuse, as it may increase the risk of dependence or addiction.

Additionally, Lunesta should be avoided by individuals with respiratory conditions such as asthma, as it may cause respiratory depression. It is important to inform the prescribing physician about any pre-existing medical conditions, medications, or supplements being taken to ensure safe and effective use of eszopiclone .

Long-term use of eszopiclone should be avoided, as it may lead to tolerance and dependence. The medication is typically prescribed for short-term use, usually no longer than 7 to 10 days. If insomnia symptoms persist beyond this period, a healthcare professional should be consulted to evaluate the underlying causes and explore alternative treatment options.

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Lunesta may interact with other medications, including opioids, sedatives, and certain antidepressants, leading to increased sedation and respiratory depression. It is important to inform the prescribing physician about all medications being taken to avoid potential drug interactions.

In conclusion, Lunesta is a medication commonly used for the short-term treatment of insomnia. It acts by enhancing the effects of GABA in the brain, promoting sleep initiation and maintenance.

While generally well-tolerated, eszopiclone can cause side effects such as headache, dry mouth, and drowsiness. It should be used with caution in specific populations and for short durations to minimize the risk of dependence. As with any medication, it is important to follow the prescribing physician’s instructions and consult a healthcare professional with any concerns or questions.

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Eszopiclone is formulated as film-coated tablets for oral administration.  LUNESTA tablets contain 1 mg, 2 mg, or 3 mg eszopiclone and the following inactive ingredients: calcium phosphate, colloidal silicon dioxide, croscarmellose sodium, hypromellose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, titanium dioxide, and triacetin. In addition, both the 1 mg and 3 mg tablets contain FD&C Blue #2.

Lunesta Dosage

The recommended starting dose is 1 mg. Dosing can be raised to 2 mg or 3 mg if clinically indicated. In some patients, the higher morning blood levels of LUNESTA following use of the 2 mg or 3 mg dose increase the risk of next day impairment of driving and other activities that require full alertness. The total dose of LUNESTA should not exceed 3 mg, once daily immediately before bedtime. Buy Lunesta Online.

Side Effects of Lunesta Tablets

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

The premarketing development program for LUNESTA included eszopiclone exposures in patients and/or normal subjects from two different groups of studies: approximately 400 normal subjects in clinical pharmacology/pharmacokinetic studies, and approximately 1550 patients in placebo-controlled clinical effectiveness studies, corresponding to approximately 263 patient-exposure years.

The conditions and duration of treatment with eszopiclone varied greatly and included (in overlapping categories) open-label and double-blind phases of studies, inpatients and outpatients, and short-term and longer-term exposure. Adverse reactions were assessed by collecting adverse events, results of physical examinations, vital signs, weights, laboratory analyses, and ECGs. Buy Lunesta Online.

Precautions:

Complex sleep behaviors including sleep-walking, sleep-driving, and engaging in other activities while not fully awake may occur following the first or any subsequent use of . eszopiclone Patients can be seriously injured or injure others during complex sleep behaviors. Such injuries may result in fatal outcomes. Other complex sleep behaviors (e.g., preparing and eating food, making phone calls, or having sex) have also been reported. Patients usually do not remember these events.

Post-marketing reports have shown that complex sleep behaviors may occur with  eszopiclone alone at recommended dosages, with or without the concomitant use of alcohol or other CNS depressants.

LUNESTA is a CNS depressant and can impair daytime function in some patients at the higher doses (2 mg or 3 mg), even when used as prescribed. Prescribers should monitor for excess depressant effects, but impairment can occur in the absence of symptoms (or even with subjective improvement), and impairment may not be reliably detected by ordinary clinical exam (i.e., less than formal psychomotor testing).

While pharmacodynamic tolerance or adaptation to some adverse depressant effects of eszopiclone  may develop, patients using 3 mg eszopiclone should be cautioned against driving or engaging in other hazardous activities or activities requiring complete mental alertness the day after use.

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