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Opana is a brand name for the medication containing the active ingredient oxymorphone. It belongs to the class of drugs known as opioid analgesics, which are commonly prescribed for the management of moderate to severe pain when other treatments have been ineffective. Oxymorphone, the primary component of Opana, works by binding to opioid receptors in the central nervous system, which helps to alleviate pain. It primarily targets the mu-opioid receptors, but it also has some affinity for delta and kappa receptors.
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Oxymorphone is available in various formulations, including immediate-release (IR) tablets, extended-release (ER) tablets, and extended-release injectable formulations. The immediate-release tablets are designed to provide rapid relief from acute pain, while the extended-release tablets are formulated to provide long-lasting pain relief over a prolonged period.
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When taken orally, Oxymorphone is absorbed into the bloodstream through the gastrointestinal tract. The onset of action for the immediate-release formulation is typically within 30 minutes, whereas the extended-release formulation may take several hours to reach its full effect.
The analgesic effects of Oxymorphone are attributed to its ability to modulate pain perception in the central nervous system. It helps reduce the transmission of pain signals and alters the brain’s response to pain, resulting in pain relief. Oxymorphone is effective in managing various types of pain, such as post-operative pain, cancer pain, and chronic pain conditions.
However, like other opioid medications, Oxymorphone carries the risk of several side effects. Common side effects include drowsiness, dizziness, constipation, nausea, vomiting, and dry mouth. These effects are dose-dependent and tend to diminish as the body adjusts to the medication. It is important to note that constipation can be severe and may require additional treatment measures.
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Opana also has the potential for more serious side effects, such as respiratory depression, sedation, and physical dependence. Respiratory depression refers to a decrease in the rate and depth of breathing, which can be life-threatening in high doses or when combined with other respiratory depressants, such as alcohol or benzodiazepines. Sedation can impair cognitive and motor functions, leading to accidents or falls. Physical dependence can occur with prolonged use, and abrupt discontinuation or rapid dose reduction may result in withdrawal symptoms.
Due to the potential for abuse and addiction, Oxymorphone is classified as a Schedule II controlled substance in the United States. It means that it has a high potential for abuse, and its use may lead to severe psychological or physical dependence. Misuse of Oxymorphone, such as taking higher doses than prescribed, crushing or snorting the tablets, or injecting the medication, can increase the risk of overdose and other adverse effects.
In recent years, there has been growing concern about the misuse of Opana, particularly when it was available in its original formulation. The original Oxymorphone ER tablets were designed to deter abuse, but individuals found ways to circumvent these mechanisms. In response to these concerns, the manufacturer voluntarily removed the original formulation from the market and introduced a reformulated version with improved abuse-deterrent properties.
It is essential to use Oxymorphone exactly as prescribed by a healthcare professional and to follow the provided instructions carefully. Never share your medication with others, and store it securely out of reach of children and individuals who might misuse it.
If you have any concerns or questions about Opana or its effects, it is crucial to consult with your healthcare provider or pharmacist. They can provide you with personalized information and guidance based on your specific situation.
Please note that the information provided here is a general overview and does not replace professional medical advice. It is always best to consult with a healthcare professional for specific questions or concerns about medications.
What To Avoid when Taken Opana pills
When taking Oxymorphone pills, it is important to be aware of certain precautions and avoid certain substances or activities that can potentially interact with the medication or increase the risk of adverse effects. Here are some important considerations:
1. Alcohol:
Avoid consuming alcohol while taking Opana. Both alcohol and Opana are central nervous system depressants, and their combined use can increase the risk of sedation, respiratory depression, and other serious side effects.
2. Other central nervous system depressants:
Opana can enhance the sedative effects of other medications that affect the central nervous system, such as benzodiazepines (e.g., diazepam, alprazolam) or sedative-hypnotics. Combining Oxymorphone with these substances can lead to excessive sedation, respiratory depression, and even coma. It is important to inform your healthcare provider about all the medications you are taking to ensure they do not interact with Opana.
3. Other opioids:
Avoid using other opioid medications while taking Oxymorphone, unless specifically instructed by your healthcare provider. Combining opioids can increase the risk of overdose, respiratory depression, and other serious side effects.
4. Others inhibitors:
Monoamine oxidase inhibitors (MAOIs), a type of antidepressant, can interact with Oxymorphone and cause serious reactions such as high body temperature, agitation, rapid heartbeat, increased blood pressure, and even a life-threatening condition known as serotonin syndrome. It is important to inform your healthcare provider about all the medications you are taking, including MAOIs.
5. Driving and operating machinery:
Oxymorphone can cause drowsiness, dizziness, and impaired cognitive function. Avoid driving or operating heavy machinery until you know how Opana affects you. These effects can be more pronounced when starting the medication or when the dose is increased.
6. Grapefruit and grapefruit juice:
Grapefruit and grapefruit juice may interact with Opana and increase the levels of the medication in your bloodstream, potentially leading to an increased risk of side effects. It is advisable to avoid consuming grapefruit or grapefruit juice while taking Oxymorphone.
7. Stool softeners and laxatives:
Oxymorphone can cause constipation, a common side effect of opioids. However, it is generally recommended to avoid using over-the-counter stool softeners or laxatives without consulting your healthcare provider. They can provide guidance on managing constipation effectively and recommend appropriate measures.
Remember, this list is not exhaustive, and it is important to discuss any concerns or potential interactions with your healthcare provider or pharmacist. They can provide personalized advice based on your medical history and current medications to ensure the safe and effective use of Opana.
Uses
Opana (Oxymorphone) is prescribed for the relief of moderate to severe pain and also as a preoperative drug to mitigate worry, maintain anesthesia and as an obstetric pain reliever. Moreover, it can be used for the mitigation of pain in patients with dyspnoea related with acute left ventricular failure and pneumonic edema.
It is practically free of antitussive activity.
Opana tablets are prescribed for the management of chronic pain and are administered only to patients already on a regular schedule of strong opioids for a long period of time.
Side Effects
- sickness with feeling to vomit
- Shallow breathing
- Cold feeling
- Dry mouth
- Dizziness
- Constipation
- Drowsiness
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