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Demerol, also known by its generic name meperidine, is a synthetic opioid analgesic medication that is used to treat moderate to severe pain. It belongs to the class of drugs called opioids, which act on the opioid receptors in the central nervous system to relieve pain. Here’s some information about Demerol in 1000 words: meperidine, was first synthesized in the 1930s by German scientists Otto Eisler and Fritz Schumann. It was initially developed as a potential alternative to morphine, with the hope of creating a less addictive and more potent pain reliever. Demerol was introduced into the United States in the 1940s and gained popularity as a prescription painkiller.
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meperidine works by binding to opioid receptors in the brain and spinal cord, inhibiting the transmission of pain signals and producing analgesic effects. It is classified as a schedule II controlled substance due to its high potential for abuse and addiction. The drug is available in various forms, including tablets, capsules, and injectable solutions.
When administered, Demerol provides rapid pain relief and can be used for acute pain management, such as after surgery or in cases of severe injury. It is also sometimes used for chronic pain conditions, although its use in this context is generally limited due to concerns about tolerance, dependence, and addiction. The dosage of Demerol is determined based on the individual’s age, weight, and the severity of their pain. It is typically administered orally, intravenously, or intramuscularly. The effects of Demerol usually begin within 15 to 30 minutes of administration and last for three to four hours.
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Like other opioid medications, Demerol carries a range of potential side effects. Common side effects include drowsiness, dizziness, nausea, vomiting, constipation, and sweating. Some individuals may also experience more serious side effects, such as respiratory depression, low blood pressure, and allergic reactions. Long-term use of Demerol can lead to physical dependence and addiction.
Due to its high abuse potential, Demerol is subject to strict regulations and control measures. It is classified as a controlled substance in many countries, and its prescription and dispensation are closely monitored. Healthcare providers are advised to exercise caution when prescribing Demerol and to closely monitor patients for signs of misuse or addiction
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meperidine Demerol should be used with caution in certain populations, such as the elderly, individuals with respiratory conditions, and those with a history of substance abuse. It is contraindicated in individuals with severe asthma, paralytic ileus, or hypersensitivity to meperidine or other opioids.
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The misuse and abuse of Meperidine can lead to serious health consequences. It is not uncommon for individuals to develop a tolerance to the drug, requiring higher doses to achieve the same level of pain relief. This can increase the risk of overdose and respiratory depression. The recreational use of Meperidine can also lead to addiction and other negative outcomes.
To mitigate the risks associated with Meperidine use, healthcare providers are encouraged to follow prescribing guidelines, closely monitor patients, and educate them about the potential dangers of opioid medications. Patients should be informed about the signs of opioid overdose and provided with resources for addiction treatment if needed.
In recent years, there has been a growing recognition of the opioid crisis and the need to address the over prescription and misuse of opioid medications. Efforts have been made to improve pain management strategies and promote the responsible use of opioids. Alternative pain management approaches, such as non-opioid medications, physical therapy, and behavioral interventions, are being explored and recommended as first-line treatments for pain.
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In conclusion, meperidine , or meperidine, is a synthetic opioid analgesic used for the treatment of moderate to severe pain. It works by binding to opioid receptors in the brain and spinal cord, providing analgesic effects. However, due to its high abuse potential and associated risks, its use is tightly regulated. Healthcare providers and patients alike should exercise caution and be aware of the potential side effects and risks associated with Demerol use.
Looking to buy Demerol online? (meperidine hydrochloride, USP) Tablet and Oral Solution are opioid agonists. meperidine Tablets are available as 50 mg and 100 mg Tablets for oral administration. The chemical name is 4-Piperidinecarboxylic acid, 1-methyl-4-phenyl-,ethyl ester, hydrochloride. The molecular weight is 283,80. Its molecular formula is C15H21NO2· HCl, and it has the following chemical structure.
DEMEROL (meperidine hydrochloride) Structural Formula Illustration
Meperidine hydrochloride is a white crystalline substance with a melting point of 186°C to 189°C. It is readily soluble in water and has a neutral reaction and a slightly bitter taste. The solution is not decomposed by a short period of boiling. meperidine . The Tablets contain 50 mg or 100 mg of meperidine hydrochloride. The DEMEROL Oral Solution is a pleasant-tasting, nonalcoholic, banana-flavored solution containing 50 mg of meperidine hydrochloride, per 5 mL (10 mg/mL).
The Inactive Ingredients in meperidine Tablets include: Calcium Sulfate, Dibasic Calcium Phosphate, Starch, Stearic Acid, and Talc. The Tablets are white, round and convex. The 50 mg is a scored tablet and has a stylized “W” on one side and “D” over “35” on the other side. The 100 mg is a scored tablet and has a stylized “W” on one side and “D” over “37” on the other side.
Demerol Dosage & Usage
Ensure accuracy when prescribing, dispensing, and administrating meperidine Oral Solution to avoid dosing errors due to confusion between mg and mL, and with other Meperidine Hydrochloride Oral Solutions of different concentrations, which could result in accidental overdose and death. Ensure the proper dose is communicated and dispensed. When writing prescriptions, include both the total dose in mg and the total dose in volume.
Do not use household teaspoons or tablespoons to measure DEMEROL Oral Solution, as using a tablespoon instead of a teaspoon could lead to over dosage. Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals.
Dilute each dose of DEMEROL oral solution in one-half glass of water because the undiluted solution may exert a slight topical anesthetic effect on mucous membranes. Initiate the dosing regimen for each patient individually; taking into account the patient’s severity of pain, patient response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse.
Precautions:
Dosing errors can result in accidental overdose and death. Avoid dosing errors that may result from confusion between mg and mL and confusion with meperidine solutions of different concentrations, when prescribing, dispensing, and administering DEMEROL Oral Solution. Ensure that the dose is communicated clearly and dispensed accurately.
Do not use a teaspoon or a tablespoon to measure a dose. A household teaspoon is not an adequate measuring device. Given the inexactitude of the household spoon measure and the risk of mistakenly using a tablespoon instead of a teaspoon, which could lead to over dosage, it is strongly recommended that caregivers obtain and use a calibrated measuring device. Healthcare providers should recommend a calibrated device that can measure and deliver the prescribed dose accurately, and instruct caregivers to use extreme caution in measuring the dosage.
The following adverse reactions associated with the use of meperidine were identified in clinical studies or postmarking reports. Because some of these reactions were reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
The major hazards of meperidine, as with other opioid analgesics, are respiratory depression and, to a lesser degree, circulatory depression, respiratory arrest, shock, and cardiac arrest. The most frequently observed adverse reactions included lightheadedness, dizziness, sedation, nausea, vomiting, and sweating. These effects seem to be more prominent in ambulatory patients and in those who are not experiencing severe pain. In such individuals, lower doses are advisable. Some adverse reactions in ambulatory patients may be alleviated if the patient lies down.
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